The school was established in 1911 by Fr. H. Colli. While the school is a Catholic educational institution, with the primary aim of providing education to local Catholic boys, students of other faiths are admitted. It is said that the school in its early days only admitted boys of fairer complexion, so that they mixed easily with Europeans and Anglo Indians.[2] The school had a humble beginning under the leadership of Fr. Colli with 35 students in 1911. In April that year, the students took the Madras Middle Certificate Examination. The school was then under the supervision of the Inspector of European Schools. In 1916, standard VII was added and the student body increased to 102. In 1918 kindergarten was added. By 1936, St. Patrick's was a full-fledged high school and celebrated its silver jubilee. The school was under the guidance of the Brothers of St. Gabriel from 1936 to 1956. They introduced the present house system among the students for healthy competition. The Archdiocese of Hyderabad took over the school in 1956 until 1973. In 1973, the administration was transferred to the Jesuit Fathers of Andhra Province, belonging to the Society of Jesus (founded by St. Ignatius of Loyola). The Jesuits brought many changes to the school. Parent visits on the second Saturday of every month was introduced. The rank system was replaced by the grade system. The old building was demolished and the playground was extended. A spacious and ventilated building was built for the kindergarten and elementary sections. The school celebrated its platinum jubilee in 1986. Computer education was introduced in 1989. In 1991, basketball, tennis, and staking courts were constructed. Remedial hour system was introduced in 1997. The St. Patrick's Old Boys Association was rejuvenated around the same time